Merlin Crossley, AM[1] is an Australian molecular biologist, university teacher, and administrator. He is Deputy Vice-Chancellor (DVC) Academic Quality at the University of New South Wales.[2]
Crossley is interested in gene regulation. He studied an unusual genetic disorder termed Haemophilia B Leyden where patients recover after puberty.[7] The condition results from mutations that disrupt the control region of the clotting factor IX gene.[8][9]
A testosterone-responsive element accounts for post-pubertal recovery.[10] He has also investigated abnormal patterns of globingene expression and his work on mutations associated with the lifelong expression of the fetal haemoglobin gene may help in the treatment of thalassemia and sickle cell anaemia.[11] He is using CRISPR-mediated gene editing to introduce beneficial mutations in cell lines as models for treating genetic diseases.[12][13] Clinical trials by major gene editing companies are now introducing mutations that his lab described.
He has contributed numerous articles on molecular genetics and education to newspapers and media outlets such as The Conversation (website)[22] and has promoted science communication, for instance as a member of the judging panel for the annual anthology, Best Australian Science Writing.[23] He is Deputy Director of the Australian Science Media Centre (AusSMC),[24] has served on the Trust of the Australian Museum 2012-20[25] and the Board of the Sydney Institute of Marine Science 2010-15,[26] and is on the Board of, and Chair of the Editorial Board of The Conversation (website).
^Funnell, AP; Crossley, M (January 2014). "Hemophilia B Leyden and once mysterious cis-regulatory mutations". Trends in Genetics. 30 (1): 18–23. doi:10.1016/j.tig.2013.09.007. PMID24138812.
^Crossley, M; Ludwig, M; Stowell, KM; De Vos, P; Olek, K; Brownlee, GG (July 1992). "Recovery from hemophilia B Leyden: an androgen-responsive element in the factor IX promoter". Science. 257 (5068): 377–9. Bibcode:1992Sci...257..377C. doi:10.1126/science.1631558. PMID1631558.
^van Vliet, J; Crofts, LA; Quinlan, KG; Czolij, R; Perkins, AC; Crossley, M (April 2006). "Human KLF17 is a new member of the Sp/KLF family of transcription factors". Genomics. 87 (4): 474–82. doi:10.1016/j.ygeno.2005.12.011. PMID16460907.