![]() | |
![]() | |
Clinical data | |
---|---|
Other names | MP; Methylhydroxyprogesterone; 6α-Methyl-17α-hydroxyprogesterone; 6α-Methyl-17α-hydroxypregn-4-en-3,20-dione |
Drug class | Progestin; Progestogen |
ATC code |
|
Legal status | |
Legal status | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.007.545 |
Chemical and physical data | |
Formula | C22H32O3 |
Molar mass | 344.495 g·mol−1 |
3D model (JSmol) | |
| |
|
Medroxyprogesterone (MP), is a progestin which is not used medically.[2][3][4][5] A derivative, medroxyprogesterone acetate (MPA), is used as a medication in humans, and is far more widely known in comparison.[6] Medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate,[6] and what is almost always being referred to when the term is used is MPA and not medroxyprogesterone.[7]
Compared to MPA, medroxyprogesterone is over two orders of magnitude less potent as a progestogen.[8] Medroxyprogesterone is also notable in that it is a minor metabolite of MPA.[9] In addition to its progestagenic activity, medroxyprogesterone is a weak antiandrogen in vitro on human androgen receptor.[10]
Compound | Ki | EC50 a | EC50b |
---|---|---|---|
Progesterone | 4.3 | 0.9 | 25 |
Medroxyprogesterone | 241 | 47 | 32 |
Medroxyprogesterone acetate | 1.2 | 0.6 | 0.15 |
Values are nM. a = Coactivator recruitment. b = Reporter cell line. |
See also: List of progestogens |
Medroxyprogesterone, also known as 6α-methyl-17α-hydroxyprogesterone or as 6α-methyl-17α-hydroxypregn-4-en-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone.[2][3] It is specifically a derivative of 17α-hydroxyprogesterone with a methyl group at the C6α position.[2][3] The generic name of medroxyprogesterone is a contraction of 6α-methyl-17α-hydroxyprogesterone. It is closely related to medrogestone as well as other unesterified 17α-hydroxyprogesterone derivatives such as chlormadinone, cyproterone, and megestrol.[2][3]
Medroxyprogesterone is the generic name of the drug and its INN and BAN .[2][3][5]
Brand Name
Meprate 10 Tablets (practo)