In organic chemistry, the Malaprade reaction or Malaprade oxidation is a glycol cleavage reaction in which a vicinal diol is oxidized by periodic acid or a periodate salt to give the corresponding carbonyl functional groups.^[1][2] The reaction was first reported by Léon Malaprade in 1928. Amino alcohols are also cleaved.

In terms of mechanism, the reaction is thought to proceed by a cyclic diester of iodine(VII).^[3]