Sport

Major League Baseball, the highest level of play in professional baseball in the U.S. and Canada.
Major League Cricket, the franchise cricket league in the U.S. Formerly referred to a U.S. company that ran professional cricket competitions.
Major League Eating, organizes top-level competitive eaters, eating events, television specials and merchandise, mostly in the U.S.
Major League Gaming, a professional league dedicated to video game competition in the U.S.
Major League Lacrosse, the highest level of play in professional field lacrosse in the U.S.
Major League Quidditch, the highest level of play in quidditch in the U.S. and Canada
Major League Rugby, the highest level of play in professional rugby union in the U.S. and Canada.
Major League Soccer, the highest level of play in professional soccer in the U.S. and Canada.
Major League Wrestling, a popular professional wrestling promotion that described itself as hybrid wrestling
Major Hockey League (disambiguation)
Major Soccer League, an indoor soccer league in the U.S. from 1978 to 1992
Tonga Major League, the highest level of association football in Tonga
Ukrainian Major League, former semi-professional ice hockey league in Ukraine, known only as the "Major League"

Arts and entertainment