Enzyme
RNMT |
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Identifiers |
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Aliases | RNMT, MET, RG7MT1, hCMT1c, CMT1, CMT1c, cm1p, hCMT1, hMet, MRNA-methyltransferase, RNA guanine-7 methyltransferase, N7-MTase |
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External IDs | OMIM: 603514 MGI: 1915147 HomoloGene: 2816 GeneCards: RNMT |
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Wikidata |
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In enzymology, a mRNA (guanine-N7-)-methyltransferase also known as mRNA cap guanine-N7 methyltransferase is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + G(5')pppR-RNA S-adenosyl-L-homocysteine + m7G(5')pppR-RNA (mRNA containing an N7-methylguanine cap)
Thus, the two substrates of this enzyme are S-adenosyl methionine and G(5')pppR-RNA, whereas its two products are S-adenosylhomocysteine and m7G(5')pppR-RNA. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases.
In humans, mRNA cap guanine-N7 methyltransferase is encoded by the RNMT gene.[5][6][7]
Nomenclature
The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase. Other names in common use include:
- messenger ribonucleate guanine 7-methyltransferase,
- guanine-7-methyltransferase,
- messenger RNA guanine 7-methyltransferase, and
- S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase.
- cap MTase