Luxembourg competed at the 2012 European Athletics Championships held in Helsinki, Finland, between 27 June to 1 July 2012. 4 competitors, 3 men and 1 woman took part in 4 events.
| Event | Athletes | Heat | Semifinal | Final | |||
|---|---|---|---|---|---|---|---|
| Result | Rank | Result | Rank | Result | Rank | ||
| 800 m | Charel Grethen | 1:53.22 | 35 | did not advance | |||
| 1500 m | David Karonei | 3:50.93 | 26 | — | did not advance | ||
| 400 m hurdles | Jacques Frisch | 51.59 | 26 | did not advance | |||
| Event | Athletes | Qualification | Final | ||
|---|---|---|---|---|---|
| Result | Rank | Result | Rank | ||
| Pole vault | Gina Reuland | 3.80 | 28 | did not advance | |