A young Star-Lord meets the Ravagers led by Yondu upon being abducted by them.

The story of Groot's old home planet is told, where it was decimated by Ronan the Accuser.

A group of robots on Halfworld enhance a space raccoon into Rocket Raccoon. It also tells how he met up with Groot.

It is revealed how Drax ended up in Nova Corps custody after he saved some prisoners from Ronan the Accuser.

Gamora is freed from Thanos' control while on a mission with Thanos' other minions known as Nebula and Korath.

Star-Lord leads his fellow team members Gamora, Drax the Destroyer, Rocket Raccoon and Groot into raiding an alien prison to spring Yondu. They learn from him that Korath the Pursuer has a Spartax artifact that he plans to give to Thanos. After getting the artifact from Korath the Pursuer, the Guardians of the Galaxy head to Knowhere (a colony in the severed head of a Celestial). While Drax, Rocket Raccoon and Groot's stick form meet Cosmo the Spacedog (who is the head of security on Knowhere), Star-Lord learns from an alien broker that he is part Spartax. When Korath the Pursuer's group and Yondu's Ravagers attack the Guardians of the Galaxy to claim the Spartax artifact, Knowhere starts to come to life and ensnare everyone.

Songs: "Hooked on a Feeling" by Blue Swede, "Funk #49" by James Gang

After the Cosmic Seed caused Knowhere to be briefly awakened and Groot to be overpowered by its energies, Korath the Pursuer snatches Star-Lord and Gamora in order to force Star-Lord to open the box for him by using a parasite that makes Gamora relive her sins. Following the rescue of Star-Lord and Gamora, Thanos leads his fleet into attacking Knowhere in order to claim the Star Seed's box. As Star-Lord uses the Continuum Cortex in Knowhere to fight Thanos' fleet, Groot helps Drax the Destroyer fight Thanos. Eventually, Cosmo uses Knowhere's technology to transport the Guardians of the Galaxy and Knowhere to a distant galaxy. After leaving Knowhere, Star-Lord discovers that the Cosmic Seed's box is a map to the Cosmic Seed.

Song: "Drift Away" by Dobie Gray

After the Guardians of the Galaxy narrowly escape a planet that Fin Fang Foom was on, Rocket Raccoon accepts an offer to work for the Collector, while the rest of the Guardians of the Galaxy look for special Pandorian Crystals needed to power the map to the Star Seed. What the rest of the Guardians of the Galaxy do not know is that the Collector has plans to add Rocket Raccoon to his collection of alien creatures due to him being the last of his kind.

Song: "Walk Away" by James Gang

The Guardians crash land on a space station called Conjunction, which is run by Grandmaster. The Grandmaster seeks to have Drax and Gamora fight each other in the Conjunction Arena. The Guardians of the Galaxy look for Pandorian Crystals from Star-Lord's old contact named Lunatik. They must also keep themselves from being busted by Nova Corps member named Titus.

Song: "The Boys Are Back in Town" by Thin Lizzy

On a planet where the next Pandorian Crystal is, the Guardians of the Galaxy find a race of aliens that are under attack by the rock-like Rexians. They fight them off. Afterwards, the Guardians go on a journey to save Groot. Groot becomes infected with the same parasitic fungus that possessed the Rexians. They also try not to get into conflict with a persistent Titus.

Titus apprehends the Guardians of the Galaxy when they try to infiltrate the Nova Corps Headquarters on Xandar even after preventing Supergiant from escaping from her prison and preventing a spaceship from crashing. As part of a deal with Titus, the Guardians infiltrate a notorious gang of weapons dealers called the Black Order (the same group that Supergiant works for which also consists of Ebony Maw, Proxima Midnight, Corvus Glaive, and Black Dwarf) who have been sighted on the desert planet of Eilsel 4. The Black Order plans to obtain the Universal Weapon that was previously used by Ronan the Accuser and give it to Thanos.

Since Ronan the Accuser has been dead, Nova Prime informs the Nova Corps that there is a power vacuum left by Ronan the Accuser's death where Korath the Pursuer, Nebula, and Gamora have been competing to be Thanos' new general. The other Guardians of the Galaxy members do not know it yet, but Gamora has come up with a plan to pit Korath the Pursuer and Nebula against each other by pretending to betray the Guardians of the Galaxy.

While at an abandoned mining facility on an unnamed planet, the Guardians of the Galaxy are attacked by super-evolved Symbiotes. They end up running into Yondu's Ravagers who are after the Cosmic Seed's map while trying to avoid the Symbiotes. After escaping both enemies, the Guardians of the Galaxy are unaware that one Symbiote stowed away. The Symbiote ends up possessing Groot, trapping Gamora and Drax in a cocoon, and changing the destination to Hala so that the Symbiotes can invade other planets. While Rocket Raccoon goes to great lengths to save Groot, Star-Lord must go to great lengths to protect the Cosmic Seed map even when the Ravagers catch up.

Song: "Shake Your Groove Thing" by Peaches & Herb

Rocket Raccoon is abducted and taken back to his home planet Halfworld. Rocket finds that all the animal life including his family have become just as enhanced as he is. When the rest of the Guardians of the Galaxy arrive on Half World, they end up helping Rocket Raccoon to fight the evolved turtle Pyko who leads his fellow evolved creatures Ranger (who is Rocket Raccoon's brother), Blackjack O'Hare (an evolved hare), and Wal Rus (an evolved walrus) on a rebellion against the Halfworld Robots that evolved them.

Song: "Funk Funk" by Cameo

The Guardians of the Galaxy encounter a living moon called Mandala which starts to make Gamora, Drax, Rocket Raccoon, and Groot act like they were before they all met as a way for Mandala to play with them. Star-Lord must work to get them back to normal even when Nebula uses Mandala's life-giving powers and a special seed to resurrect Ronan the Accuser.

Song: "Joy to the World" by Three Dog Night

When they need to get a Repulsar Generator to get through a gravity storm, the Guardians of the Galaxy cut a deal with the Collector on Knowhere. In exchange for the Repulsar Generator, the Guardians of the Galaxy must deliver a herd of Moombas, which Drax is cautious around to Conjunction in two days. The Collector even warns them to feed them nothing but grass as anything else can make them explode. Outside of the Moombas getting the Guardians of the Galaxy away from the Nova Corps, they are soon targeted by the Ravagers who have been hired by the Grandmaster to take the explosive Moombas back to the Collector.

The Guardians of the Galaxy get caught up with the Inhumans' Royal Family at the time when they have come down with a plague and must protect their space-faring city of Attilan from Ronan the Accuser as well as thwart the takeover plans of Maximus and his crystallized Alpha Primitives.

The Guardians of the Galaxy come across the Destroyer Armor on a planet where Rocket Raccoon activates it during an attack by the Black Order. When the Destroyer Armor is brought to Knowhere, Rocket Raccoon uses it to deal with a bar patron that insulted him until he starts to lose control. Drax goes up against the Destroyer Armor to see who is the better destroyer even when Loki shows up on Knowhere.

Star-Lord goes missing while he was translating the readings of the CryptoCube.

The Guardians of the Galaxy stumble upon a plan by Ronan the Accuser to blow up the Supreme Intelligence as they work to thwart Ronan's plot.

The Guardians of the Galaxy suddenly find themselves in Asgard. While trying to figure out the origins of the Cosmic Seed, they must outwit Thor and Angela.