IS061 RNA | |
---|---|
![]() Predicted secondary structure and sequence conservation of IS061 | |
Identifiers | |
Symbol | IS061 |
Rfam | RF00115 |
Other data | |
RNA type | Gene; sRNA |
Domain(s) | Bacteria |
SO | SO:0001263 |
PDB structures | PDBe |
The ISO61 (IsrA) RNA is a bacterial non-coding RNA that is found between the abgR and ydaL genes in Escherichia coli and Shigella flexneri. It was discovered using a computational screen of the E. coli genome.[1] Subsequent characterisation of ISO61 region has revealed that the reverse strand is actually a CsrA binding ncRNA called McaS and that it has a role in biofilm formation control.[2] Furthermore, it has been shown that McaS(IsrA) exists as ribonucleoprotein particles (sRNPs), which involve a defined set of proteins including Hfq, S1, CsrA, ProQ and PNPase. [3]