High Frontier may refer to:

• The High Frontier, a 1976 book about space colonization by Gerard K. O'Neill
• High Frontier, Inc., an American think tank established in the 1980s by former Lieutenant General Daniel O. Graham
• High Frontier (video game), a 1987 video game by ZX Spectrum games
• High Frontier (board game), a 2010 board wargame by Sierra Madre
• The High Frontier (album), 2013 album by American band Lumerians