Henry Blake may refer to:

• Sir Henry Arthur Blake (1840–1918), British colonial administrator and Governor of Hong Kong
• Henry Blake (baseball) (1874–1919), American baseball player
• Henry Blake (lighthouse keeper) (1837–1871), American lighthouse keeper
• Sir Henry Charles Blake, 4th Baronet (1794–1880), of the Blake baronets
• Henry N. Blake (1838–1935), first chief justice of the Montana Supreme Court after statehood

Fictional characters

• Henry Blake (M*A*S*H), a character in the television series M*A*S*H