Helix (database), database management system for the Apple Macintosh platform, created in 1983
Helix (multimedia project), a project to produce computer software that can play audio and video media in various formats, aid in producing such media, and serve them over a network
Helix, a market payment service with an integrated bitcoin tumbler by the darknet-market search engine Grams.
Helix ALM, formerly called TestTrack, software for managing requirements, defects, issues and testing throughout the software development cycle developed by Seapine Software
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