Game of the Century may refer to:

Sports

• The Game of the Century (chess), a chess game between Donald Byrne and Bobby Fischer in 1956
• Game of the Century (college basketball), a basketball game between the Houston Cougars and UCLA Bruins in 1968
• Game of the Century (college football), any one of several games in U.S. college football
• Italy v West Germany (1970 FIFA World Cup), the semi-final of the 1970 FIFA World Cup between Italy and West Germany
• The Game of the Century (Go), a game of Go between Honinbo Shusai and Go Seigen in 1934
• The Game of the Century (rugby union), a 1905 match between Wales and New Zealand, also known as the Match of the Century

Television

• The Game of the Century (TV series), 1978 British TV series