FuFi-1 | |
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![]() Consensus secondary structure and sequence conservation of FuFi-1 RNA | |
Identifiers | |
Symbol | FuFi-1 |
Rfam | RF02986 |
Other data | |
RNA type | Gene; sRNA |
SO | SO:0001263 |
PDB structures | PDBe |
The FuFi-1 RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] Such RNA "motifs" are often the first step to elucidating the biological function of a novel RNA.[2] FuFi-1 motif RNAs are found in Bacillota AND Fusobacteriota.
FuFi-1 RNAs are sometimes located in the vicinity of genes that encode XRE-like proteins, an example of a helix-turn-helix structure. However, XRE-like proteins are very common in bacteria, and therefore it is unclear that this association represents an important biological connection. Also, while the XRE-like genes are often located nearby to the FuFi-1 RNAs, the RNAs are not positioned so that they could be consistently located in the 5' untranslated region of the genes. Therefore, FuFi-1 RNAs likely function in trans as small RNAs. Predicted Rho-independent transcription terminator hairpins occur on the 3' part of the FuFi-1 RNA motif, suggesting that they terminate transcripts containing the RNA motif. These transcription terminators were predicting using the RNie program.[3]