From 1984 to 1993 he worked for Boeing, rising to the level of Senior Principal Scientist. In 1993 he joined Texas Tech University,[3][4] as assistant professor with a joint appointment to the Department of Electrical and Computer Engineering, and Computer Science. In 1998, he was promoted to associate professor.[5]
In 1999, he left Texas for the Missouri University of Science and Technology, becoming Mary K. Finley Distinguished Professor in the Department of Electrical and Computer Engineering, with courtesy appointments in the departments of System Engineering, Computer Science, and Business Administration.[3]
Khalid Al-Jabery, Gayla Olbricht, Tayo Obafemi-Ajayi and Donald C. Wunsch II, Computational Learning Approaches to Data Analytics in Biomedical Applications, Elsevier, 2019. ISBN9780128144831
J. Sieffertt and D.C. Wunsch, Unified Computational Intelligence for Complex Systems: Studies in Neural, Economic and Social Dynamics. Springer-Verlag, 2010. ISBN9783642031809
E. Kussul, T. Baidyk, and D.C. Wunsch II, Neural Networks in Micromechanics, Springer-Verlag, 2010.
R. Xu and D.C. Wunsch II, Clustering. IEEE Press / Wiley, 2009. ISBN9780470382783
Gorban, Alexander N., Balázs Kégl, Donald C. Wunsch, and Andrei Y. Zinovyev. 2008. Principal Manifolds for Data Visualization and Dimension Reduction. Springer 2008
The most highly cited of his papers, according to Google Scholar,[6] are
Prokhorov, D.V. and Wunsch, D.C., 1997. Adaptive critic designs. IEEE transactions on Neural Networks, 8(5), pp. 997–1007. (cited 1182 times)
Saad, Emad W., Danil V. Prokhorov, and Donald C. Wunsch. "Comparative study of stock trend prediction using time delay, recurrent and probabilistic neural networks." IEEE Transactions on neural networks 9.6 (1998): 1456–1470. (cited 578times)
Li, Shuhui, Donald C. Wunsch, Edgar A. O'Hair, and Michael G. Giesselmann. "Using neural networks to estimate wind turbine power generation." IEEE Transactions on energy conversion 16, no. 3 (2001): 276–282. (cited 392 times)
Xu, Rui, and Donald C. Wunsch. "Clustering algorithms in biomedical research: a review." IEEE reviews in biomedical engineering 3 (2010): 120–154.(cited 230 times)