DExH-box helicase 29 (DHX29) is a 155 kDa protein that in humans is encoded by the DHX29 gene.[5]
Function
This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection.[6] This protein may also play a role in sensing virally derived cytosolic nucleic acids.[7] Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells.[8]