The Church of the Nativity of the Blessed Virgin Mary (Chinese: 圣母圣诞堂) is a Catholic church in Singapore. It is located at Upper Serangoon Road in the Hougang Planning Area, within Singapore's North-East Region.
The church was constructed in 1901, and is the oldest Catholic church for the Teochew community in Serangoon.
The origins of this Catholic church can be traced to an attap (thatched roof) chapel that was built in 1853 on Upper Serangoon Road, its congregation comprising mainly Teochew farmers living in Serangoon and Punggol. Subsequently, a brick chapel was built in the area and named St Mary's Church. Father Jean Casimir Saleilles, parish priest from 1881 to 1911, was responsible for building the present church in 1901.
Father Saleilles also helped to spread the Catholic faith to Johor. He founded the Church of Our Lady of Lourdes (Johor), later renamed the Church of the Immaculate Conception and subsequently designated a cathedral.
The Church of the Nativity of the Blessed Virgin Mary was gazetted as a national monument on 14 January 2005.