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Nuclear power plants in the United States are supervised by the Nuclear Regulatory Commission which oversees them in four regions:

• NRC Region One, located in King of Prussia, Pennsylvania, oversees the north-eastern United States.
• NRC Region Two, located in Atlanta, Georgia, oversees the south-eastern United States.
• NRC Region Three, located in Lisle, Illinois, oversees the northern mid-western United States
• NRC Region Four, located in Arlington, Texas, oversees the southern midwestern and the western United States.

For a list of all reactors in the United States according to region, see: List of nuclear reactors#United States of America.