Brandywine Creek may refer to:

Canada

• Brandywine Creek (British Columbia), a tributary of the Cheakamus River

United States

• Brandywine Creek (Big Blue River), in Indiana
• Brandywine Creek (St. Joseph River tributary), in Michigan
• Brandywine Creek (Broken Sword Creek tributary), Crawford County, Ohio
• Brandywine Creek (Cuyahoga River tributary), in Summit County, Ohio
• Brandywine Creek (Quittapahilla Creek tributary), in Lebanon County, Pennsylvania
• Brandywine Creek (Christina River tributary), in Chester County, Pennsylvania and New Castle County, Delaware
  • East Branch Brandywine Creek, in Chester County, Pennsylvania
  • West Branch Brandywine Creek, in Chester County, Pennsylvania
• Brandywine Creek State Park, in New Castle County, Delaware
• Battle of Brandywine Creek, during the American Revolutionary War (1777)