betaine-aldehyde dehydrogenase
Betaine aldehyde dehydrogenase tetramer, Staphylococcus aureus
Identifiers
EC no.	1.2.1.8
CAS no.	9028-90-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a betaine-aldehyde dehydrogenase (EC 1.2.1.8) is an enzyme that catalyzes the chemical reaction

betaine aldehyde + NAD⁺ + H₂O ${\displaystyle \rightleftharpoons }$ betaine + NADH + 2 H⁺

The 3 substrates of this enzyme are betaine aldehyde, NAD⁺, and H₂O, whereas its 3 products are betaine, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is betaine-aldehyde:NAD+ oxidoreductase. Other names in common use include betaine aldehyde oxidase, BADH, betaine aldehyde dehydrogenase, and BetB. This enzyme participates in glycine, serine and threonine metabolism.

As of late 2007^[update], 4 structures have been solved for this class of enzymes, with PDB accession codes 1A4S, 1BPW, 1WNB, and 1WND.

• ROTHSCHILD HA, BARRON ES (1954). "The oxidation of betaine aldehyde by betaine aldehyde dehydrogenase". J. Biol. Chem. 209 (2): 511–23. doi:10.1016/S0021-9258(18)65478-X. PMID 13192104.
• Tsutui N, Hirasawa E (2003). "Purification and properties of betaine aldehyde dehydrogenase from Avena sativa". J. Plant Res. 116 (2): 133–40. doi:10.1007/s10265-003-0077-7. PMID 12736784. S2CID 23668905.
• L; González-Segura, L; Mújica-Jiménez, C; Contreras-Díaz, L (2003). "Ligand-induced conformational changes of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa and Amaranthus hypochondriacus L. leaves affecting the reactivity of the catalytic thiol". Chem. Biol. Interact. 143–144: 129–37. doi:10.1016/S0009-2797(02)00197-7. PMID 12604197.
• Eklund H; El-Ahmad, M; Ramaswamy, S; Hjelmqvist, L; Jörnvall, H; Eklund, H (1998). "Structure of betaine aldehyde dehydrogenase at 2.1 A resolution". Protein Sci. 7 (10): 2106–17. doi:10.1002/pro.5560071007. PMC 2143847. PMID 9792097.
• Takabe T; Tanaka, Y; Aoki, K; Hibino, T; Jikuya, H; Takano, J; Takabe, T; Takabe, T (2003). "Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica". J. Biol. Chem. 278 (7): 4932–42. doi:10.1074/jbc.M210970200. PMID 12466265.