Protein-coding gene in humans
B-cell CLL/lymphoma 7 protein family member A is a protein that in humans is encoded by the BCL7A gene located in the chromosome 12 (Cytogenetic band: 12q24.31).[5]
Function
This gene codifies for a protein that belongs to the SWI/SNF chromatin remodelling complex, a complex that is able to modify the interations between DNA and histones using the energy of the ATP hydrolysis . It has found recurrently mutated in lymphomas [6] and silenced by promoter hypermetylation in haematological malignancies .[7] [8]
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This article incorporates text from the United States National Library of Medicine , which is in the public domain .