Combination of | |
---|---|
Atenolol | Beta blocker |
Chlorthalidone | Diuretic |
Clinical data | |
Trade names | Tenoretic, Tenoret, others |
AHFS/Drugs.com | FDA Professional Drug Information |
License data | |
Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status | |
Identifiers | |
CAS Number | |
PubChem CID | |
KEGG |
Atenolol/chlorthalidone, also known as co-tenidone, is a combination medication used to treat high blood pressure.[2][3] It is made up of atenolol, a beta-blocker and chlortalidone, a diuretic.[4] It is not recommended as an initial treatment but may be used in those who are taking atenolol and chlortalidone individually.[5] It is taken by mouth.[2]
Common side effects include gastrointestinal upset and gout.[3] Serious side effects may include liver problems, pancreatitis, and psychosis.[3] Use is not recommended during pregnancy.[3] Use during breastfeeding may harm the baby.[2] Atenolol works by blocking β1-adrenergic receptors in the heart, thus decreasing the heart rate and workload.[3] Chlorthalidone works by increasing the amount of sodium lost by the kidneys.[2]
The combination was approved for medical use in the United States in 1984.[4] It is available as a generic medication.[3] In 2017, it was the 304th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[6]