Arch, the protein archaerhodopsin-3, a light-driven proton pump used for research in optogenetics, a technology for controlling brain activity using light
Arch Linux, a Linux distribution that emphasizes simplicity
GNU arch, in software, a source code management tool
RetroArch, a free and open source emulator for a wide variety of games.
Branchial arches, a series of bony "loops" present in fish, which support the gill
ARCH Air Medical Service (Area Rescue Consortium of Hospitals), providing critical care air ambulance service in Missouri, Illinois, and the surrounding regions
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