Debuts
Domestic
- 7 January - The Biggest Loser (e.tv) (2008)
- 27 January - Are You Smarter than a 5th Grader? (M-Net) (2008)
International
- 9 January -
The Big Bang Theory (M-Net) - 15 January - Damages (M-Net)
- 22 January - Pushing Daisies (M-Net)
- 24 January - Private Practice (M-Net)
- 1 February - Phineas and Ferb (Disney Channel)
- 4 February - K-Ville (M-Net Action)
- 7 February -
Supernova (BBC Prime) - 29 February - Wizards of Waverly Place (Disney Channel)
- 3 March - George of the Jungle (Cartoon Network)
- 5 March - Samantha Who? (M-Net)
- 27 March - Life (M-Net)
- 28 March - //
/
Animalia (SABC2) - 15 April - Californication (M-Net)
- 15 April - Saving Grace (M-Net)
- 28 April - Tyler Perry's House of Payne (SABC1)
- 5 May - My Spy Family (Cartoon Network)
- 5 May - Breaking Bad (M-Net Action)
- 10 May -
/ Eliot Kid (Cartoon Network) - 12 May - Chowder (Cartoon Network)
- 25 May - Mad Men (M-Net)
- 2 June - Army Wives (M-Net)
- 4 June - Chuck (M-Net)
- 12 June - Eli Stone (M-Net)
- 4 July - Low Winter Sun (UK) (BBC Prime)
- 4 July - The Adrenaline Project (Go)
- 11 August -
bro'Town (Go) - 22 August - Moonlight (M-Net Action)
- 1 September - / Chop Socky Chooks (Cartoon Network)
- 3 September - Burn Notice (M-Net)
- 4 September -
Home Salvage (The Home Channel) - 4 September - Total Drama Island (Cartoon Network)
- 29 September - Lipstick Jungle (SABC3)
- 2 October - Orange Roughies (Go)
- 6 October - Little Miss Jocelyn (Go)
- 9 October - The Return of Jezebel James (M-Net)
- 10 October - Cavemen (M-Net)
- 12 October - Tracey Ullman's State of the Union (M-Net)
- 16 October - Greek (Go)
- 27 October - The Guard (M-Net Series)
- 11 November - Sons of Anarchy (M-Net)
- 17 November - The Bill Engvall Show (M-Net)
- 26 November - In Treatment (M-Net Series)
- 2 December - Raising the Bar (M-Net)
- 11 December - Rules of Engagement (SABC3)
- 12 December - Fear Itself (M-Net Action)
- Bo on the Go! (M-Net)
- Roary the Racing Car (M-Net)
- The Beeps (M-Net)
- Will and Dewitt (SABC2)
- DinoSquad (M-Net)
- /// The Tudors (M-Net)
- Being Ian (M-Net)
- Rupert Bear, Follow the Magic... (K-T.V. World)
- In the Night Garden... (CBeebies)
- Charlie and Lola (CBeebies)