AKT1 |
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Estruturas disponíveis |
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PDB | Pesquisa Human UniProt: PDBe RCSB |
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Lista de códigos id do PDB |
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1H10, 1UNP, 1UNQ, 1UNR, 2UVM, 2UZR, 2UZS, 3CQU, 3CQW, 3MV5, 3MVH, 3O96, 3OCB, 3OW4, 3QKK, 3QKL, 3QKM, 4EJN, 4EKK, 4EKL, 4GV1, 5KCV |
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Identificadores |
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Nomes alternativos | AKT1 |
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IDs externos | OMIM: 164730 HomoloGene: 3785 GeneCards: AKT1 |
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Doenças Geneticamente Relacionadas |
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cancro colorretal, síndrome de Proteus, cancro da mama, Síndrome de Cowden[1] |
Ontologia genética |
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Função molecular | • GTPase activating protein binding • kinase activity • nitric-oxide synthase regulator activity • ATP binding • protein kinase activity • protein phosphatase 2A binding • enzyme binding • phosphatidylinositol-3,4,5-trisphosphate binding • transferase activity • 14-3-3 protein binding • GO:0001948, GO:0016582 ligação a proteínas plasmáticas • protein serine/threonine/tyrosine kinase activity • protein kinase binding • protein kinase C binding • nucleotide binding • phosphatidylinositol-3,4-bisphosphate binding • identical protein binding • protein serine/threonine kinase activity • protein homodimerization activity • calmodulin binding
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Componente celular | • citoplasma • citosol • membrane • cell-cell junction • mitocôndria • núcleo celular • ciliary basal body • microtubule cytoskeleton • membrana plasmática • fuso mitótico • cariolinfa • vesícula • postsynapse • GO:0009327 complexo macromolecular
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Processo biológico | • germ cell development • positive regulation of glucose import • cellular response to nerve growth factor stimulus • positive regulation of protein phosphorylation • positive regulation of lipid biosynthetic process • regulation of neuron projection development • activation-induced cell death of T cells • response to heat • regulation of cell cycle checkpoint • response to organic substance • response to insulin-like growth factor stimulus • positive regulation of endodeoxyribonuclease activity • cellular response to DNA damage stimulus • regulation of protein localization • platelet activation • protein phosphorylation • cellular response to mechanical stimulus • negative regulation of long-chain fatty acid import across plasma membrane • negative regulation of fatty acid beta-oxidation • cell projection organization • cellular response to granulocyte macrophage colony-stimulating factor stimulus • positive regulation of blood vessel endothelial cell migration • glucose metabolic process • glycogen metabolic process • regulation of glycogen biosynthetic process • glycogen cell differentiation involved in embryonic placenta development • cell population proliferation • negative regulation of autophagy • cellular response to hypoxia • negative regulation of cell size • endocrine pancreas development • GO:0006859 carbohydrate transport • negative regulation of proteolysis • insulin-like growth factor receptor signaling pathway • GO:0051247, GO:0051200 positive regulation of protein metabolic process • positive regulation of glycogen biosynthetic process • glucose homeostasis • labyrinthine layer blood vessel development • GO:0001306 response to oxidative stress • negative regulation of gene expression • positive regulation of peptidyl-serine phosphorylation • cellular response to prostaglandin E stimulus • positive regulation of cell growth • positive regulation of nitric-oxide synthase activity • maternal placenta development • regulation of myelination • protein ubiquitination • positive regulation of vasoconstriction • hyaluronan metabolic process • spinal cord development • cellular response to insulin stimulus • cellular response to decreased oxygen levels • protein autophosphorylation • inflammatory response • positive regulation of fat cell differentiation • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • negative regulation of neuron death • G protein-coupled receptor signaling pathway • diferenciação celular • cellular response to peptide • negative regulation of protein kinase activity • fosforilação • regulation of mRNA stability • negative regulation of release of cytochrome c from mitochondria • execution phase of apoptosis • GO:1904579 cellular response to organic cyclic compound • positive regulation of DNA-binding transcription factor activity • positive regulation of glucose metabolic process • nervous system development • response to fluid shear stress • maintenance of protein location in mitochondrion • GO:0044257 Oxidação de aminoácidos • negative regulation of protein kinase activity by protein phosphorylation • osteoblast differentiation • response to UV-A • response to hormone • peptidyl-threonine phosphorylation • lipopolysaccharide-mediated signaling pathway • positive regulation of protein localization to nucleus • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • GO:0007243 intracellular signal transduction • regulation of cell migration • peripheral nervous system myelin maintenance • nitric oxide biosynthetic process • positive regulation of endothelial cell proliferation • síntese proteica • positive regulation of nitric oxide biosynthetic process • cellular response to growth factor stimulus • T cell costimulation • regulation of nitric-oxide synthase activity • GO:0010260 envelhecimento • mammary gland epithelial cell differentiation • cellular response to epidermal growth factor stimulus • multicellular organism development • negative regulation of JNK cascade • glycogen biosynthetic process • establishment of protein localization to mitochondrion • apoptotic mitochondrial changes • GO:0035404 peptidyl-serine phosphorylation • GO:0061423 positive regulation of sodium ion transport • response to growth hormone • positive regulation of apoptotic process • response to food • cellular response to vascular endothelial growth factor stimulus • striated muscle cell differentiation • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of fibroblast migration • regulation of translation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 transdução de sinal • negative regulation of endopeptidase activity • GO:0097285 apoptose • positive regulation of epidermal growth factor receptor signaling pathway • interleukin-18-mediated signaling pathway • GO:1901047 insulin receptor signaling pathway • positive regulation of smooth muscle cell proliferation • regulation of signal transduction by p53 class mediator • negative regulation of macroautophagy • TOR signaling • anoikis • positive regulation of organ growth • I-kappaB kinase/NF-kappaB signaling • phosphatidylinositol 3-kinase signaling • GO:0072353 cellular response to reactive oxygen species • NIK/NF-kappaB signaling • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • cellular response to cadmium ion • positive regulation of I-kappaB phosphorylation • epidermal growth factor receptor signaling pathway • positive regulation of cell population proliferation • positive regulation of mitochondrial membrane potential • regulation of apoptotic process • negative regulation of apoptotic process • positive regulation of protein localization to plasma membrane • carbohydrate metabolic process • activation of protein kinase B activity • protein kinase B signaling • negative regulation of protein kinase B signaling • potencial pós-sináptico excitatório • cellular response to tumor necrosis factor • cell migration involved in sprouting angiogenesis • GO:1901313 positive regulation of gene expression • cytokine-mediated signaling pathway • negative regulation of protein ubiquitination • negative regulation of protein binding • positive regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of Notch signaling pathway • negative regulation of protein serine/threonine kinase activity • cellular response to oxidised low-density lipoprotein particle stimulus • positive regulation of G1/S transition of mitotic cell cycle • negative regulation of leukocyte cell-cell adhesion • positive regulation of protein localization to cell surface • negative regulation of lymphocyte migration • protein import into nucleus
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Sources:Amigo / QuickGO |
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Wikidata |
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AKT1, do inglês V-akt murine thymoma viral oncogene homolog 1, é uma enzima que em humanos é codificada pelo gene AKT1.
A proteína quinase serina/treonina codificada pelo gene AKT1 está cataliticamente inactiva em fibroblastos privados de soro e em fibroblastos imortalizados. AKT1 e o ATK2 são activados por factores de crescimento derivados de plaquetas. A activação é rápida e específica, não sendo anulada por mutações no domínio de homologia a plecstrina da AKT1. Foi demonstrado que a activação ocorre através do fosfoinositol 3-quinase.
No sistema nervoso em desenvolvimento, o AKT é um mediador crítico da sobrevivência neuronal induzida por factores de crescimento. Os factores de crescimento podem suprimir a apoptose de uma maneira independente de transcrição, por activação da quinase serina/treonina AKT1, que depois fosforila e inactiva componentes da apoptose.
Múltiplos variantes de transcriptos, que sofreram splicing alternativo, foram encontrados para este gene.[3]
Ratos que não possuem AKT1 mostram uma redução em 25% da massa corporal, indicando que este gene é fundamental para que os sinais dos factores de crescimento sejam transmitidos, mais provavelmente através do receptor IGF1. Os ratos que não possuem AKT1 são também resistentes ao cancro: apresentam atrasos consideráveis no crescimento de tumores iniciados, por exemplo pelo oncogene NEU.
Interações
AKT1 mostrou interação com Phosphoinositide-dependent kinase-1,[4][5] Keratin 10,[6] Integrin-linked kinase,[4][5][7] TSC2,[8][9] GAB2,[10] TRIB3,[11] NPM1,[12] BRCA1,[13][14] BRAF,[15] C-Raf,[16] MAPK14,[17] MARK2,[18] MAP2K4,[19] MTCP1,[20][21] TCL1A,[20][21][22] Nerve Growth factor IB,[23] MAPKAPK2,[17] PRKCQ,[24] Androgen receptor,[25] Heat shock protein 90kDa alpha (cytosolic), member A1,[26][27][28] Plexin A1,[29] MAP3K11,[30] TSC1,[8][9] MAP3K8,[31] Mammalian target of rapamycin,[32][33][34] PKN2,[35] AKTIP,[36] YWHAZ,[37] CHUK[38][39] e CDKN1B.[40]