William Keen or Keene may refer to:

Entertainment

• William Keene (1915–1992), American TV actor
• Bill Keene (1927–2000), American television and radio personality
• William B. Keene (1925–2018), American attorney, judge and television judge
• Will Keen (born 1970), English actor

Other

• William Keen (merchant) (1680s–1754), merchant and judicial officer in the British colony of Newfoundland
• William Keen (cricketer) (1792–1846), English amateur cricketer
• William Williams Keen (1837–1932), pioneer American brain surgeon
• William John Keen (1873–1958), Chief Commissioner of the North-West Frontier Province of British India
• Bill Keen (1892–1947), American baseball player