Red blood cells (erythrocytes) from donors contain normal hemoglobin (HbA), and transfusion of normal red blood cells into people with sickle cell disease reduces the percentage of red cells in the circulation containing the abnormal hemoglobin (HbS).[1] Although transfusion of donor red blood cells can ameliorate and even prevent complications of sickle cell disease in certain circumstances, transfusion therapy is not universally beneficial in sickle cell disease.[2]
There are two main types of transfusion, simple red cell transfusion and exchange transfusion.
Involves transfusing red blood cells without removing any of the patient’s blood.[3] It is used when the patient's hemoglobin is much lower than normal, for example an aplastic crisis.[4]
Exchange transfusion involves removal of the patient’s blood and replacement with donor red blood cells.[3] It is used to treat life-threatening complications of sickle cell disease such as stroke or acute chest crisis.[4]
There are three main benefits of an exchange transfusion compared to a simple transfusion, these relate primarily to the ability to remove hemoglobin S containing red blood cells:[5]
However, there are also potential risks associated with an exchange transfusion:
The exchange is performed using a machine (pheresis). This method rapidly and substantially reduces the concentration of sickle cells within the blood without increasing the overall hematocrit or blood viscosity.[citation needed]
The exchange is performed manually. It refers to manually phlebotomizing a percentage of the patient’s blood prior to or concomitantly with giving a red cell transfusion.[citation needed]
Red cell transfusions can be further classified as episodic or chronic.[3]
Episodic transfusion is used either acutely in response to a complication of sickle cell disease such as acute chest syndrome or to prevent complications prior to surgery.[3]
Chronic transfusion is used when sustained, low levels of HbS are needed to prevent sickle cell-related complications, most commonly stroke in children.[3]
Transfusion therapy for sickle-cell disease entails the use of red blood cell transfusions in the management of acute cases of sickle cell disease and as a prophylaxis to prevent complications by decreasing the number of red blood cells (RBC) that can sickle by adding normal red blood cells.[citation needed]
In children prophylactic chronic red blood cell (RBC) transfusion therapy has been shown to be efficacious to a certain extent in reducing the risk of first stroke or silent stroke when transcranial Doppler (TCD) ultrasonography shows abnormal increased cerebral blood flow velocities. In those who have sustained a prior stoke event it also reduces the risk of recurrent stroke and additional silent strokes.[6][7][8] There is no evidence for the use of red blood cell transfusion in adults to prevent primary stroke, although it is recommended to prevent secondary stroke.[8][9][10][11]
In children and adults red blood cell transfusion to increase the hemoglobin level to 100 g/L has been shown to decrease the risk of sickle cell-related complications.[2] However, this has not been seen in all studies, and has only been demonstrated for African haplotypes of Hemoglobin SS.[12][13]
In children who have been given transfusions to prevent stroke there was also a reduction in the number of children who developed acute chest crises.[13] There is no evidence about whether or not red cell transfusions prevent chronic lung complications.[14]
This should be suspected if there is a significant drop in the hemoglobin level compared to the patient's usual hemoglobin level which is associated with a low level of reticulocytes. This is usually due to infection with erythrovirus B19 (previously known as parvovirus B19).[11] The anemia is usually severe with an average drop in hemoglobin of 40 g/L, and is usually treated with a simple transfusion.[11]
Acute splenic and hepatic sequestration associated with severe anemia requires a simple transfusion to raise the hemoglobin.[3][11]
Red cell transfusions are used to treat patients with acute chest crisis and respiratory compromise.[9][2] Exchange transfusion is recommended for those patients who have a higher hemoglobin (> 90g/L), those who have not improved after a simple transfusion, or those who have severe respiratory compromise.[11]