François-Vincent Toussaint (1715–1772), author of Les Mœurs ("The Manners") published in 1748 and immediately prosecuted and burned by the French court of justice
Lorraine Toussaint (born 1960), television actress best known for playing assistant medical examiner Elaine Duchamps on the television drama Crossing Jordan
Toussaint Charbonneau (1767–1843), French-Canadian explorer and trader, member of the Lewis and Clark Expedition, best known as the husband of Sacagawea
Toussaint Louverture (1743–1803), freed black slave and former French general who led the Haitian Revolution expelling the French, British, and Spanish armies that enforced slavery in Haiti and nearby Santo Domingo
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