Ruki may refer to:

• Ruki sound law, a phonological law in some Indo-European branches
• Ruki, Iran, a village in Razavi Khorasan Province, Iran
• Ruki River, a tributary of the Congo River in the Democratic Republic of the Congo
• Loki dialect or Ruki, a language spoken in the Democratic Republic of the Congo

In popular culture

• Ruki, vocalist from the Japanese rock band The Gazette
• Rika Nonaka, a Digimon Tamers character
• Ruki, a type of Neopet