Clinical data | |
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AHFS/Drugs.com | International Drug Names |
Routes of administration | Oral |
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Pharmacokinetic data | |
Elimination half-life | 2-2.5 hours |
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CAS Number | |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.043.012 |
Chemical and physical data | |
Formula | C17H22N4O |
Molar mass | 298.390 g·mol−1 |
3D model (JSmol) | |
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Minaprine (INN, USAN, BAN; brand names Brantur, Cantor) is a monoamine oxidase inhibitor antidepressant drug[2] that was used in France for the treatment of depression until it was withdrawn from the market in 1996 because it caused convulsions.[3]
A study found that it acts as a reversible inhibitor of MAO-A (RIMA) in rats.[4] It has also been found to weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.[5]
It has demonstrated significant antibiotic activity against M. chelonae and M. abscessus in tests with antibiotic resistant bacteria.[6]
Minaprine is a member of pyridazines, a secondary amine and a member of morpholines. It has a role as an antidepressant, a serotonin uptake inhibitor, a dopamine uptake inhibitor, a cholinergic drug and an antiparkinson drug.[7]