Clinical data | |
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Trade names | Manyper, Caldine, etc. |
AHFS/Drugs.com | International Drug Names |
Routes of administration | Oral |
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Chemical and physical data | |
Formula | C35H38N4O6 |
Molar mass | 610.711 g·mol−1 |
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Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.[1][2][3][4][5]
It was patented in 1982 and approved for medical use in 1990.[6]
The alkylation between N-(2-hydroxyethyl)piperazine [103-76-4] (1) and Benzhydryl Bromide [776-74-9] (2) gives 2-(4-benzhydrylpiperazin-1-yl)ethanol [10527-64-7] (3). The reaction with Diketene [674-82-8] (4) gives 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate [89226-49-3] (5). The reaction with 3-nitrobenzaldehyde [99-61-6] (6) and Methyl 3-aminocrotonate [14205-39-1] (7) completed the synthesis of Manidipine (8).
Simple piperazines (no additional rings) | |
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Phenylpiperazines |
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Diphenylalkylpiperazines (benzhydrylalkylpiperazines) |
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Pyrimidinylpiperazines | |
Pyridinylpiperazines | |
Benzo(iso)thiazolylpiperazines | |
Tricyclics (piperazine attached via side chain) |
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Others/Uncategorized |