Clinical data | |
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AHFS/Drugs.com | Micromedex Detailed Consumer Information |
MedlinePlus | a682683 |
Pregnancy category |
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Routes of administration | Oral |
ATC code |
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Legal status |
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Pharmacokinetic data | |
Bioavailability | Negligible |
Metabolism | Nil |
Excretion | Fecal and renal |
Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.115.465 |
Chemical and physical data | |
Formula | AlMg2(OH)7·H2O |
Molar mass | 212.66 g/mol |
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Magaldrate (INN) is a common antacid drug that is used for the treatment of duodenal and gastric ulcers, esophagitis from gastroesophageal reflux.
Magaldrat was first synthesized by the German chemist Gunther Hallmann and patented on February 2, 1960, by Byk Gulden Lomberg Chemische Fabrik (Germany).[1] In 1983, the active substance was registered as the original drug Riopan.[2]
Magaldrate is available in the form of oral suspension or tablets.
Magaldrate is a hydroxymagnesium aluminate complex that is converted rapidly by gastric acid into Mg(OH)2 and Al(OH)3, which are absorbed poorly and thus provide a sustained antacid effect.[3]
Magaldrate may negatively influence drugs like tetracyclines, benzodiazepines, and indomethacin. High doses or prolonged usage may lead to an increment of defecation and a reduction in feces consistence. In some cases it can alter the functionality of the gastrointestinal tract, occasionally provoking constipation or diarrhea.