Mitochondrially encoded tRNA threonine also known as MT-TT is a transfer RNA which in humans is encoded by the mitochondrialMT-TTgene.[3]
Structure
The MT-TT gene is located on the p arm of the non-nuclear mitochondrial DNA at position 12 and it spans 66 base pairs.[4] The structure of a tRNA molecule is a distinctive folded structure which contains three hairpin loops and resembles a three-leafed clover.[5]
Function
MT-TT is a small 66 nucleotide RNA (human mitochondrial map position 15888-15953) that transfers the amino acid threonine to a growing polypeptide chain at the ribosome site of protein synthesis during translation.
^Graham BH, Waymire KG, Cottrell B, Trounce IA, MacGregor GR, Wallace DC (July 1997). "A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator". Nature Genetics. 16 (3): 226–34. doi:10.1038/ng0797-226. PMID9207786. S2CID7285265.
^Grasbon-Frodl EM, Kösel S, Sprinzl M, von Eitzen U, Mehraein P, Graeber MB (April 1999). "Two novel point mutations of mitochondrial tRNA genes in histologically confirmed Parkinson disease". Neurogenetics. 2 (2): 121–7. doi:10.1007/s100480050063. PMID10369889. S2CID13031885.
^Yoon KL, Aprille JR, Ernst SG (May 1991). "Mitochondrial tRNA(thr) mutation in fatal infantile respiratory enzyme deficiency". Biochemical and Biophysical Research Communications. 176 (3): 1112–5. doi:10.1016/0006-291X(91)90399-R. PMID1645537.
^Reference, Genetics Home. "MT-TT gene". Genetics Home Reference.
^Nishino I, Seki A, Maegaki Y, Takeshita K, Horai S, Nonaka I, Goto Y (August 1996). "A novel mutation in the mitochondrial tRNA(Thr) gene associated with a mitochondrial encephalomyopathy". Biochemical and Biophysical Research Communications. 225 (1): 180–5. doi:10.1006/bbrc.1996.1150. PMID8769114.