Protein-coding gene in the species Homo sapiens
ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4 gene.[5][6]
ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus.[7] MRP4/ABCC4 also transports prostaglandins, for example PGE2, out of the cell where they can bind receptors.[8]
MRP4/ABCC4 expression is dysregulated in several cancers [9][10][11] and is also upregulated in peritoneal endometriosis.[12]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
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Fluorouracil (5-FU) Activity
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Membrane proteins, carrier proteins: membrane transport proteins ABC transporter (TC 3A1)