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Names | |
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Preferred IUPAC name
5-(Hydroxymethyl)-2,4-dimethylpyridin-3-ol | |
Identifiers | |
3D model (JSmol)
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ChemSpider | |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C8H11NO2 | |
Molar mass | 153.181 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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4-Deoxypyridoxine is a vitamin B6 antagonist.[1] It may be toxic to developing embryos since it can have negative effects on collagen and elastin during development.[2] The presence of this compound can produce vitamin B6 deficiency, which suppresses the immune system.[3] 4-Deoxypyridoxine lowers vitamin B6 concentration by competitively inhibiting some of the enzymes necessary for the regeneration of vitamin B6.[4] The related immunosuppression can be beneficial in animal models of Trichinella spiralis infections.[5] 4-Deoxypyridoxine has also been described as an inhibitor of sphingosine-1-phosphate lyase.[6] The inhibition of sphingosine-1-phosphate lyase by 4-deoxypyridoxine has been shown to prevent cell death of ex vivo animal pancreatic islets. The use of 4-deoxypyridoxine to prevent stress-induced apoptosis is suggest that the compound, as well as other inhibitors of sphingosine-1-phosphate lyase, could be used to increase the viability of donor pancreatic tissue in the treatment of diabetes.[7]