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ECHA InfoCard | 100.045.926 ![]() |
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Formula | C12H17N |
Molar mass | 175.275 g·mol−1 |
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4-Benzylpiperidine is a drug and research chemical used in scientific studies. It acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It is most efficacious as a releaser of norepinephrine, with an EC50 of 109 nM (DA), 41.4 nM (NE) and 5246 nM (5-HT).[1] It has a fast onset of action and a short duration.[1] It also functions as a monoamine oxidase inhibitor (MAOI) with preference for MAO-A.[2]
4-Cyanopyridine can be reacted with toluene to give 4-benzylpyridine.[3] Catalytic hydrogenation of the pyridine ring then completes the synthesis.[4]