Before stage 3, Team BikeExchange–Jayco voluntarily withdrew from the race after two unspecified members of their squad tested positive for COVID-19.[6] Before stage 4, Team Jumbo–Visma and Team DSM followed suit after two and three unspecified members, respectively, of both teams tested positive. On the other hand, Movistar Team opted to continue racing after two riders, Juri Hollmann and Einer Rubio, tested positive after stage 1, though both riders were withdrawn.[7] As a result, only 117 of the 159 riders who started the race finished.[5]
On stage 2, Aleksandr Vlasov, who was second in the points classification, wore the orange jersey, because first-placed Remco Evenepoel wore the yellow jersey as the leader of the general classification. For the same reason, Fabio Jakobsen wore the orange jersey on stage 3, while Carlos Rodríguez, who was second in the young rider classification, wore the white jersey on stages 2 and 3.
On stages 4 and 5, Carlos Rodríguez, who was third in the points classification, wore the orange jersey, because first-placed Aleksandr Vlasov wore the yellow jersey as the leader of the general classification, and second-placed Remco Evenepoel wore the white jersey as the leader of the young rider classification.